scholar.google.com › citations
Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE ...
Missing: Hydrolase
People also ask
What drugs are beta-secretase inhibitors?
What is the role of beta-secretase in Alzheimer's disease?
Why did Bace inhibitors fail?
What are BACE1 B secretase inhibitors for the treatment of Alzheimer's disease?
The γ-secretase appears as a complex of proteins ... design of small molecule BACE1 inhibitors. ... disease associated with 3-hydroxy-3-methyglutaryl coenzyme A ...
DRUG DESIGN / HYDROLASE-HYDROLASE INHIBITOR complex ... Cathepsin D, subunit A; domain 1 / Acid Proteases ... Title: Structure-based design of highly selective beta ...
Nov 15, 2007 · The γ-secretase appears as a complex of ... BACE1 remains a prime drug target for inhibiting the production of Aβ. ... disease associated with 3 ...
ALZHEIMER'S DISEASE / ASPARTIC PROTEASE ... ZYMOGEN / HYDROLASE-HYDROLASE INHIBITOR complex. Function ... Cathepsin D, subunit A; domain 1 / Acid Proteases ...
People also search for
Jun 30, 2014 · β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease ... a suitable protease for the development of inhibitor ...
Aug 30, 2021 · The η-secretase pathway is an alternative rescue pathway when BACE1 is inhibited, causing a functional shift with increased Aη-α activity and ...
Mar 10, 2022 · Here, we disclose a class of 6-chlorotacrine (huprine)–TPPU hybrids as dual inhibitors of the enzymes soluble epoxide hydrolase (sEH) and ...
Feb 4, 2015 · Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious beta-secretase inhibitors for the potential treatment of Alzheimer's ...
We report that sEH is predominantly expressed in astrocytes and is elevated in postmortem brain tissue from patients with AD and in the 5xFAD β amyloid mouse ...